Buy advocin danofloxacin injection, containing Danofloxacin as its active ingredient, is a broad-spectrum fluoroquinolone antibiotic primarily used in veterinary medicine. This injectable solution is designed to treat bovine respiratory disease (BRD) and other bacterial infections in cattle. Advocin is known for its quick action against Gram-negative bacteria, including strains that are commonly involved in respiratory diseases.

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Active Ingredient: Danofloxacin

• Danofloxacin: A fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes. This inhibition prevents bacterial DNA replication, ultimately leading to bacterial cell death. Danofloxacin is effective against a wide range of Gram-negative bacteria and some Gram-positive organisms.

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Primary Uses of Advocin: Buy advocin danofloxacin injection

1. Bovine Respiratory Disease (BRD): Advocin is specifically labeled for the treatment of BRD cause by Mannheimia haemolytica. Pasteurella multocida, and Histophilus somni, which are the most common bacterial pathogens involve in the disease. These bacteria often cause severe lung infections that can rapidly lead to significant health issues in cattle, particularly in feedlot operations.
2. Other Bacterial Infections: While Advocin is primarily used for BRD. It can also be used in certain cases of acute bovine mastitis or enteric infections caused by susceptible bacteria.

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Mechanism of Action

Danofloxacin, the active ingredient in Advocin, works by disrupting bacterial DNA synthesis. Specifically, it targets bacterial enzymes, DNA gyrase and topoisomerase IV. Which are necessary for DNA replication and transcription. Without these enzymes functioning properly, bacteria cannot reproduce, leading to cell death.

Advocin’s rapid bactericidal action makes it particularly effective in treating acute bacterial infections in cattle. It also has a post-antibiotic effect. Meaning that bacterial growth continues to be inhibited even after the drug concentration has dropped below detectable levels in the bloodstream.

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Dosage and Administration

Advocin is administer by subcutaneous (SC) injection. Typically in the neck region of cattle. The specific dosage depends on the weight of the animal and the severity of the infection.

• Recommended Dosage for BRD:
  • A single dose of 6 mg/kg (2 mL/45 kg or 100 lbs of body weight), administer subcutaneously.
  • Alternatively, a dose of 8 mg/kg (2 mL/37.5 kg or 83 lbs) can be administer once, follow by a second dose 48 hours later. For severe infections.
• Re-treatment: If clinical signs persist, a second dose may be necessary. But this should be done under veterinary guidance.

It is important to avoid injecting more than 15 mL per injection site to reduce the risk of tissue irritation. The withdrawal period and milk discard times must also be followed strictly.

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Benefits of Advocin

1. Rapid Bactericidal Action: Danofloxacin is rapidly absorbed and starts working quickly. Providing fast relief from symptoms of bacterial infections. This is particularly useful in acute cases of BRD where early treatment can prevent serious complications.
2. Broad-Spectrum Activity: Advocin is effective against a wide range of Gram-negative pathogens. Making it suitable for treating a variety of bacterial infections in cattle.
3. Convenient Dosing: The single-dose or two-dose regimen makes Advocin easy to use in herd management. Reducing the need for multiple treatments and limiting stress on the animals.
4. Post-Antibiotic Effect: Even after the drug concentration decreases in the body. Its bactericidal effect persists, providing continued protection against bacterial growth.
5. Low Tissue Irritation: When injected properly, Advocin has a low risk of causing tissue irritation. Which is crucial in ensuring the comfort and well-being of the treated animal.

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Side Effects and Precautions

Although Advocin is generally safe when used according to veterinary guidelines, there are some potential side effects and precautions to consider:

1. Injection Site Reactions: As with many injectable drugs, there can be minor swelling or inflammation at the injection site, although this is typically mild and resolves on its own.
2. Development of Antibiotic Resistance: Overuse or improper administration of Danofloxacin can contribute to the development of antibiotic-resistant bacteria. To prevent this, it’s crucial to follow the recommended dosages and treatment duration as prescribed by a veterinarian.
3. Use in Dairy Cattle: Advocin is not approved for use in dairy cattle over 20 months of age or in lactating cows. This is to avoid contamination of milk with antibiotic residues.
4. Withdrawal Periods:
   • Meat: Animals treated with Advocin must be withheld from slaughter for 4 days after the last treatment to ensure no antibiotic residues remain in the meat.
   • Milk: Advocin is not labeled for use in lactating dairy cows, so a withdrawal period for milk does not apply. However, it is critical not to use the drug in animals that will soon be entering milk production.
5. Use in Calves: Advocin should not be used in calves intended for veal production due to concerns over antibiotic residues and withdrawal times.
6. Restricted Use in Food-Producing Animals: In some countries, the use of fluoroquinolones like Danofloxacin in food-producing animals is restricted due to concerns about the potential development of antibiotic-resistant bacteria.

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Resistance Management

Antimicrobial resistance is a significant concern in veterinary medicine. To reduce the risk of resistance development, Advocin should only be use when absolutely necessary and should not be overused in routine herd management. Proper diagnostic testing to identify the causative bacteria and their susceptibility to Danofloxacin can help in making informed treatment decisions.

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Conclusion

Advocin (Danofloxacin Injection) 250 mL is a highly effective treatment for bovine respiratory disease (BRD) and other bacterial infections in cattle cause by Gram-negative pathogens. Its rapid bactericidal action, convenient dosing. And broad-spectrum activity make it a valuable tool for veterinarians and livestock. Producers dealing with respiratory outbreaks in feedlots or other cattle operations.

However, due attention must be given to withdrawal periods, proper dosing, and the potential for antibiotic resistance. When used responsibly, Advocin provides fast and effective relief from bacterial infections. Helping to ensure the health and productivity of the herd. Buy advocin danofloxacin injection