Description

AMIGLYDE-V Sulfate Injection is an injectable aminoglycoside antibiotic used in veterinary medicine, particularly for horses. It is effective against a wide range of Gram-negative and some Gram-positive bacteria. The drug is commonly used to treat infections in horses and other animals when sensitivity testing confirms its efficacy.

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AMIGLYDE-V Sulfate Injection

1. Active Ingredient: Amikacin sulfate.
2. Formulation: Sterile injectable solution.
3. Indications: Treatment of bacterial infections, particularly those caused by Gram-negative organisms like E. coli, Pseudomonas spp., and Klebsiella spp.

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Uses in Horses

1. Joint Infections (Septic Arthritis):
   • Intra-articular administration for treating bacterial infections in the joints.
2. Soft Tissue Infections:
   • Effective for abscesses, cellulitis, and other soft tissue infections.
3. Urogenital Infections:
   • Used for infections in the urinary or reproductive tracts.
4. Abdominal Infections:
   • Administered for peritonitis or intra-abdominal infections.
5. Prophylactic Use:
   • Occasionally used during or after surgeries to prevent infection in high-risk cases.

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Dosage and Administration

1. Route:
   • Administered via intravenous (IV), intramuscular (IM), or intra-articular (IA) injection.
2. Dosage:
   • Systemic Administration (IV or IM): Typically, 10–15 mg/kg body weight once daily or as prescribed.
   • Intra-Articular Administration: 250–500 mg per joint, based on veterinarian discretion.
3. Treatment Duration:
   • Usually administered for 3–7 days for systemic infections or longer if necessary, based on clinical response and veterinarian recommendations.

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Benefits

1. Broad Spectrum of Activity:
   • Effective against resistant Gram-negative bacteria and some Gram-positive strains.
2. Localized Effectiveness:
   • Ideal for targeted treatment when administered intra-articularly.
3. Quick Onset:
   • Rapid bactericidal activity due to its aminoglycoside mechanism.

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Precautions

1. Nephrotoxicity:
   • Amikacin can be nephrotoxic, particularly with prolonged use. Ensure proper hydration and monitor kidney function.
2. Ototoxicity:
   • Potential risk of damage to hearing or balance. Use cautiously in horses at risk.
3. Pregnancy:
   • Use only under strict veterinary supervision in pregnant mares.
4. Drug Interactions:
   • Avoid concurrent use with other nephrotoxic or ototoxic drugs (e.g., NSAIDs, furosemide).
5. Sensitivity Testing:
   • Ideal to perform bacterial culture and sensitivity testing before administration.

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Side Effects

1. Localized Pain or Swelling:
   • May occur at the injection site.
2. Kidney Damage:
   • Monitor blood urea nitrogen (BUN) and creatinine levels during treatment.
3. Allergic Reactions:
   • Rare but possible. Watch for signs of anaphylaxis.

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Storage

• Store in a cool, dry place at temperatures between 2°C to 8°C (36°F to 46°F).
• Protect from light and avoid freezing.

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Conclusion

AMIGLYDE-V is a potent antibiotic for managing bacterial infections in horses, particularly those involving joints, soft tissues, or the urogenital system. Its efficacy and rapid action make it a valuable tool for veterinarians. However, its potential for nephrotoxicity and ototoxicity necessitates careful monitoring. Always follow the veterinarian’s recommendations for safe and effective use.